Multimeric threading-based prediction of proteinâ•fiprotein interactions on a genomic scale: Application to the Saccharomyces cerevisiae proteome
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چکیده
Multimeric threading-based prediction of protein–protein interactions on a genomic scale: Application to the Saccharomyces cerevisiae proteome.
منابع مشابه
Multimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome.
MULTIPROSPECTOR, a multimeric threading algorithm for the prediction of protein-protein interactions, is applied to the genome of Saccharomyces cerevisiae. Each possible pairwise interaction among more than 6000 encoded proteins is evaluated against a dimer database of 768 complex structures by using a confidence estimate of the fold assignment and the magnitude of the statistical interfacial p...
متن کاملMULTIPROSPECTOR: an algorithm for the prediction of protein-protein interactions by multimeric threading.
In this postgenomic era, the ability to identify protein-protein interactions on a genomic scale is very important to assist in the assignment of physiological function. Because of the increasing number of solved structures involving protein complexes, the time is ripe to extend threading to the prediction of quaternary structure. In this spirit, a multimeric threading approach has been develop...
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